Drug interactions
Cocaine + Sertraline
Severity: Moderate
Cocaine and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cocaine blocks reuptake of serotonin, dopamine and norepinephrine, so combining it with sertraline may add serotonergic effects. Topical anesthetic use gives low systemic exposure, but misuse or systemic exposure could cause serotonin toxicity or cardiovascular stimulation.
What this interaction means in plain words
Cocaine and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cocaine belongs to Central Nervous System; Sertraline belongs to Central Nervous System.
Why it happens
Additive serotonin reuptake inhibition.
What to do
For topical medical use no change is generally required, but watch for agitation, tachycardia and hyperthermia. Counsel patients to avoid recreational cocaine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Cocaine
- Cocaine + Isocarboxazid Contraindicated
- Cocaine + Phenelzine Contraindicated
- Cocaine + Procarbazine Contraindicated
- Amitriptyline + Cocaine Major
- Bisoprolol + Cocaine Major
- Citalopram + Cocaine Major
Frequently asked questions
Can I take Cocaine with Sertraline?
MediHelp rates the interaction as moderate. Cocaine and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cocaine blocks reuptake of serotonin, dopamine and norepinephrine, so combining it with sertraline may add serotonergic effects. Topical anesthetic use gives low systemic exposure, but misuse or systemic exposure could cause serotonin toxicity or cardiovascular stimulation.
How serious is the interaction between Cocaine and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For topical medical use no change is generally required, but watch for agitation, tachycardia and hyperthermia. Counsel patients to avoid recreational cocaine.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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