Drug interactions
Cocaine + Sumatriptan
Severity: Minor
Cocaine and Sumatriptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Topical cocaine is used as a local anesthetic and has small systemic exposure, but it inhibits monoamine reuptake and might add serotonergic effects to sumatriptan. Cocaine can also cause vasoconstriction, which could add to the vascular effects of the triptan.
What this interaction means in plain words
Cocaine and Sumatriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cocaine belongs to Central Nervous System; Sumatriptan belongs to Central Nervous System.
Why it happens
Theoretical additive serotonergic and vasoconstrictive effects from cocaine reuptake inhibition combined with triptan 5-HT1B/1D agonism.
What to do
No routine change is needed with limited topical use; monitor for serotonin toxicity or chest pain if large amounts are applied. Avoid triptans after illicit cocaine use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sumatriptan
- Almotriptan + Sumatriptan Contraindicated
- Dihydroergotamine intranasal + Sumatriptan Contraindicated
- Dihydroergotamine + Sumatriptan Contraindicated
- Eletriptan + Sumatriptan Contraindicated
- Ergoloid mesylates + Sumatriptan Contraindicated
- Ergotamine + Sumatriptan Contraindicated
Other interactions of Cocaine
- Cocaine + Isocarboxazid Contraindicated
- Cocaine + Phenelzine Contraindicated
- Cocaine + Procarbazine Contraindicated
- Amitriptyline + Cocaine Major
- Bisoprolol + Cocaine Major
- Citalopram + Cocaine Major
Frequently asked questions
Can I take Cocaine with Sumatriptan?
MediHelp rates the interaction as minor. Cocaine and Sumatriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Topical cocaine is used as a local anesthetic and has small systemic exposure, but it inhibits monoamine reuptake and might add serotonergic effects to sumatriptan. Cocaine can also cause vasoconstriction, which could add to the vascular effects of the triptan.
How serious is the interaction between Cocaine and Sumatriptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed with limited topical use; monitor for serotonin toxicity or chest pain if large amounts are applied. Avoid triptans after illicit cocaine use.
What other medicines interact with Sumatriptan?
MediHelp also lists interactions of Sumatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Sumatriptan page.
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