Drug interactions
Codeine + Prasugrel
Severity: Moderate
Codeine and Prasugrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids slow gastric emptying and can delay and reduce absorption of oral prasugrel's active metabolite, potentially weakening early antiplatelet effect. This matters most in acute coronary syndrome or PCI.
What this interaction means in plain words
Codeine and Prasugrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Codeine belongs to Musculoskeletal; Prasugrel belongs to Cardiovascular.
Why it happens
Opioid-induced delayed gastric emptying reduces the rate and extent of prasugrel absorption.
What to do
Avoid opioids where possible around loading of prasugrel in acute coronary syndrome. Consider a parenteral antiplatelet agent if an opioid is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Codeine
- Alvimopan + Codeine Contraindicated
- Codeine + Isocarboxazid Contraindicated
- Codeine + Olanzapine / samidorphan Contraindicated
- Codeine + Phenelzine Contraindicated
- Codeine + Tranylcypromine Contraindicated
- Alfentanil + Codeine Major
Other interactions of Prasugrel
Frequently asked questions
Can I take Codeine with Prasugrel?
MediHelp rates the interaction as moderate. Codeine and Prasugrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids slow gastric emptying and can delay and reduce absorption of oral prasugrel's active metabolite, potentially weakening early antiplatelet effect. This matters most in acute coronary syndrome or PCI.
How serious is the interaction between Codeine and Prasugrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid opioids where possible around loading of prasugrel in acute coronary syndrome. Consider a parenteral antiplatelet agent if an opioid is required.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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