Drug interactions
Colestipol + Cyanocobalamin
Severity: Minor
Colestipol and Cyanocobalamin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bile acid sequestrants can bind vitamin B12 in the gut and may reduce its absorption, especially during long-term therapy. Clinically significant deficiency is uncommon but possible with poor dietary intake.
What this interaction means in plain words
Colestipol and Cyanocobalamin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Colestipol belongs to Cardiovascular; Cyanocobalamin belongs to Miscellaneous.
Why it happens
Colestipol binds B12 in the intestinal lumen and interferes with absorption.
What to do
Separate oral B12 from colestipol by at least 4 hours. Monitor B12 status in long-term users.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyanocobalamin
Other interactions of Colestipol
- Amlodipine-hydrochlorothiazide-valsartan + Colestipol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Colestipol Moderate
- Atenolol-chlorthalidone + Colestipol Moderate
- Azilsartan-chlorthalidone + Colestipol Moderate
- Candesartan-hydrochlorothiazide + Colestipol Moderate
- Captopril-hydrochlorothiazide + Colestipol Moderate
Frequently asked questions
Can I take Colestipol with Cyanocobalamin?
MediHelp rates the interaction as minor. Colestipol and Cyanocobalamin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bile acid sequestrants can bind vitamin B12 in the gut and may reduce its absorption, especially during long-term therapy. Clinically significant deficiency is uncommon but possible with poor dietary intake.
How serious is the interaction between Colestipol and Cyanocobalamin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate oral B12 from colestipol by at least 4 hours. Monitor B12 status in long-term users.
What other medicines interact with Cyanocobalamin?
MediHelp also lists interactions of Cyanocobalamin with, for example, Chloramphenicol, Dichlorphenamide, Metformin. The full list is on the Cyanocobalamin page.
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