Drug interactions
Colestipol + Fludrocortisone
Severity: Minor
Colestipol and Fludrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colestipol is a bile acid sequestrant that can bind other oral drugs in the gut and reduce their absorption. Binding of fludrocortisone could lower its exposure and weaken its mineralocorticoid effect, although the clinical impact is not well documented.
What this interaction means in plain words
Colestipol and Fludrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Colestipol belongs to Cardiovascular; Fludrocortisone belongs to Endocrine.
Why it happens
Adsorption of fludrocortisone to the resin in the gastrointestinal tract reduces its absorption.
What to do
Give fludrocortisone at least 1 hour before or 4 hours after colestipol, and monitor blood pressure and electrolytes if the response changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Colestipol and Fludrocortisone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fludrocortisone
Other interactions of Colestipol
- Amlodipine-hydrochlorothiazide-valsartan + Colestipol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Colestipol Moderate
- Atenolol-chlorthalidone + Colestipol Moderate
- Azilsartan-chlorthalidone + Colestipol Moderate
- Candesartan-hydrochlorothiazide + Colestipol Moderate
- Captopril-hydrochlorothiazide + Colestipol Moderate
Frequently asked questions
Can I take Colestipol with Fludrocortisone?
MediHelp rates the interaction as minor. Colestipol and Fludrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Colestipol is a bile acid sequestrant that can bind other oral drugs in the gut and reduce their absorption. Binding of fludrocortisone could lower its exposure and weaken its mineralocorticoid effect, although the clinical impact is not well documented.
How serious is the interaction between Colestipol and Fludrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give fludrocortisone at least 1 hour before or 4 hours after colestipol, and monitor blood pressure and electrolytes if the response changes.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
