Drug interactions
Colestipol + Imipramine
Severity: Minor
Colestipol and Imipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colestipol can bind imipramine in the gut and reduce its oral absorption, which may lower antidepressant effect. The clinical impact is generally small but may matter in patients who are stable on a given dose.
What this interaction means in plain words
Colestipol and Imipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Colestipol belongs to Cardiovascular; Imipramine belongs to Central Nervous System.
Why it happens
Bile acid sequestrant resin binds the tricyclic in the gastrointestinal tract, reducing absorption.
What to do
Give imipramine at least 1 hour before or 4 to 6 hours after colestipol. Monitor depressive symptoms if timing cannot be separated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Colestipol
- Amlodipine-hydrochlorothiazide-valsartan + Colestipol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Colestipol Moderate
- Atenolol-chlorthalidone + Colestipol Moderate
- Azilsartan-chlorthalidone + Colestipol Moderate
- Candesartan-hydrochlorothiazide + Colestipol Moderate
- Captopril-hydrochlorothiazide + Colestipol Moderate
Frequently asked questions
Can I take Colestipol with Imipramine?
MediHelp rates the interaction as minor. Colestipol and Imipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Colestipol can bind imipramine in the gut and reduce its oral absorption, which may lower antidepressant effect. The clinical impact is generally small but may matter in patients who are stable on a given dose.
How serious is the interaction between Colestipol and Imipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give imipramine at least 1 hour before or 4 to 6 hours after colestipol. Monitor depressive symptoms if timing cannot be separated.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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