Drug interactions
Colestipol + Meloxicam
Severity: Moderate
Colestipol and Meloxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bile acid sequestrants bind acidic drugs in the gut, and the related resin cholestyramine is known to increase meloxicam clearance and reduce its absorption and half-life. Colestipol may reduce meloxicam exposure similarly and blunt its efficacy.
What this interaction means in plain words
Colestipol and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colestipol belongs to Cardiovascular; Meloxicam belongs to Musculoskeletal.
Why it happens
Binding of meloxicam in the gastrointestinal tract by the resin reduces absorption and interrupts enterohepatic recirculation.
What to do
Give meloxicam at least 1 hour before or 4 to 6 hours after colestipol. Monitor analgesic response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Colestipol
- Amlodipine-hydrochlorothiazide-valsartan + Colestipol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Colestipol Moderate
- Atenolol-chlorthalidone + Colestipol Moderate
- Azilsartan-chlorthalidone + Colestipol Moderate
- Candesartan-hydrochlorothiazide + Colestipol Moderate
- Captopril-hydrochlorothiazide + Colestipol Moderate
Frequently asked questions
Can I take Colestipol with Meloxicam?
MediHelp rates the interaction as moderate. Colestipol and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bile acid sequestrants bind acidic drugs in the gut, and the related resin cholestyramine is known to increase meloxicam clearance and reduce its absorption and half-life. Colestipol may reduce meloxicam exposure similarly and blunt its efficacy.
How serious is the interaction between Colestipol and Meloxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give meloxicam at least 1 hour before or 4 to 6 hours after colestipol. Monitor analgesic response.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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