Drug interactions
Colestipol + Minocycline
Severity: Moderate
Colestipol and Minocycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colestipol, a bile acid sequestrant, can bind oral minocycline in the gut and reduce its absorption. This may lower minocycline levels and lead to reduced antibacterial effectiveness.
What this interaction means in plain words
Colestipol and Minocycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colestipol belongs to Cardiovascular; Minocycline belongs to Anti Bacterial.
Why it happens
Colestipol binds minocycline in the gastrointestinal tract, reducing its absorption.
What to do
Give oral minocycline at least 2 hours before or 4 to 6 hours after colestipol. Monitor clinical response to the antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Minocycline
- Acitretin + Minocycline Contraindicated
- Isotretinoin + Minocycline Contraindicated
- Cholera vaccine + Minocycline Major
- Methoxyflurane + Minocycline Major
- Minocycline + Palovarotene Major
- Minocycline + Pexidartinib Major
Other interactions of Colestipol
- Amlodipine-hydrochlorothiazide-valsartan + Colestipol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Colestipol Moderate
- Atenolol-chlorthalidone + Colestipol Moderate
- Azilsartan-chlorthalidone + Colestipol Moderate
- Candesartan-hydrochlorothiazide + Colestipol Moderate
- Captopril-hydrochlorothiazide + Colestipol Moderate
Frequently asked questions
Can I take Colestipol with Minocycline?
MediHelp rates the interaction as moderate. Colestipol and Minocycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colestipol, a bile acid sequestrant, can bind oral minocycline in the gut and reduce its absorption. This may lower minocycline levels and lead to reduced antibacterial effectiveness.
How serious is the interaction between Colestipol and Minocycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oral minocycline at least 2 hours before or 4 to 6 hours after colestipol. Monitor clinical response to the antibiotic.
What other medicines interact with Minocycline?
MediHelp also lists interactions of Minocycline with, for example, Acitretin, Isotretinoin, Cholera vaccine. The full list is on the Minocycline page.
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