Drug interactions
Colestipol + Odevixibat
Severity: Moderate
Colestipol and Odevixibat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colestipol can bind odevixibat in the gut and reduce its absorption and local activity at the ileal bile acid transporter. This may reduce efficacy.
What this interaction means in plain words
Colestipol and Odevixibat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colestipol belongs to Cardiovascular; Odevixibat belongs to Gastrointestinal Tract.
Why it happens
Binding of odevixibat to the bile acid sequestrant in the gastrointestinal lumen.
What to do
Give odevixibat at least 4 hours before or 4 hours after colestipol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Odevixibat
- Cholestyramine + Odevixibat Moderate
- Colesevelam + Odevixibat Moderate
Other interactions of Colestipol
- Amlodipine-hydrochlorothiazide-valsartan + Colestipol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Colestipol Moderate
- Atenolol-chlorthalidone + Colestipol Moderate
- Azilsartan-chlorthalidone + Colestipol Moderate
- Candesartan-hydrochlorothiazide + Colestipol Moderate
- Captopril-hydrochlorothiazide + Colestipol Moderate
Frequently asked questions
Can I take Colestipol with Odevixibat?
MediHelp rates the interaction as moderate. Colestipol and Odevixibat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colestipol can bind odevixibat in the gut and reduce its absorption and local activity at the ileal bile acid transporter. This may reduce efficacy.
How serious is the interaction between Colestipol and Odevixibat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give odevixibat at least 4 hours before or 4 hours after colestipol.
What other medicines interact with Odevixibat?
MediHelp also lists interactions of Odevixibat with, for example, Cholestyramine, Colesevelam. The full list is on the Odevixibat page.
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