Drug interactions
Colesevelam + Odevixibat
Severity: Moderate
Colesevelam and Odevixibat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Odevixibat acts locally in the ileum as an ileal bile acid transporter inhibitor, and bile acid sequestrants can bind it in the gut. This may reduce its availability and therapeutic effect.
What this interaction means in plain words
Colesevelam and Odevixibat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colesevelam belongs to Endocrine; Odevixibat belongs to Gastrointestinal Tract.
Why it happens
Intestinal binding of odevixibat by the bile acid sequestrant reduces its effect at the ileal transporter.
What to do
Give colesevelam at least 4 hours before or after odevixibat and monitor clinical response such as pruritus and serum bile acids.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Colesevelam
- Amlodipine-olmesartan-hydrochlorothiazide + Colesevelam Moderate
- Amlodipine-olmesartan + Colesevelam Moderate
- Chenodiol + Colesevelam Moderate
- Cholic acid + Colesevelam Moderate
- Colesevelam + Cyclosporin Moderate
- Colesevelam + Glibenclamide Moderate
Other interactions of Odevixibat
- Cholestyramine + Odevixibat Moderate
- Colestipol + Odevixibat Moderate
Frequently asked questions
Can I take Colesevelam with Odevixibat?
MediHelp rates the interaction as moderate. Colesevelam and Odevixibat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Odevixibat acts locally in the ileum as an ileal bile acid transporter inhibitor, and bile acid sequestrants can bind it in the gut. This may reduce its availability and therapeutic effect.
How serious is the interaction between Colesevelam and Odevixibat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give colesevelam at least 4 hours before or after odevixibat and monitor clinical response such as pruritus and serum bile acids.
What other medicines interact with Colesevelam?
MediHelp also lists interactions of Colesevelam with, for example, Amlodipine-olmesartan-hydrochlorothiazide, Amlodipine-olmesartan, Chenodiol. The full list is on the Colesevelam page.
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