Drug interactions
Colestipol + Propranolol
Severity: Moderate
Colestipol and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colestipol can reduce or delay the absorption of propranolol, which may weaken beta-blockade. The effect is mostly relevant when colestipol is started or withdrawn.
What this interaction means in plain words
Colestipol and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colestipol belongs to Cardiovascular; Propranolol belongs to Cardiovascular.
Why it happens
Colestipol binds propranolol in the gastrointestinal tract, reducing its absorption.
What to do
Give propranolol at least 1 hour before or 4 hours after colestipol. Monitor heart rate and blood pressure when colestipol is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Colestipol
- Amlodipine-hydrochlorothiazide-valsartan + Colestipol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Colestipol Moderate
- Atenolol-chlorthalidone + Colestipol Moderate
- Azilsartan-chlorthalidone + Colestipol Moderate
- Candesartan-hydrochlorothiazide + Colestipol Moderate
- Captopril-hydrochlorothiazide + Colestipol Moderate
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Frequently asked questions
Can I take Colestipol with Propranolol?
MediHelp rates the interaction as moderate. Colestipol and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colestipol can reduce or delay the absorption of propranolol, which may weaken beta-blockade. The effect is mostly relevant when colestipol is started or withdrawn.
How serious is the interaction between Colestipol and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give propranolol at least 1 hour before or 4 hours after colestipol. Monitor heart rate and blood pressure when colestipol is started or stopped.
What other medicines interact with Colestipol?
MediHelp also lists interactions of Colestipol with, for example, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide, Atenolol-chlorthalidone. The full list is on the Colestipol page.
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