Drug interactions
Collagenase clostridium histolyticum + Dalteparin
Severity: Moderate
Collagenase clostridium histolyticum and Dalteparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Collagenase injections frequently cause bruising and bleeding at the injection site, and anticoagulants may increase the risk of hematoma. Labeling advises against anticoagulants except low-dose aspirin.
What this interaction means in plain words
Collagenase clostridium histolyticum and Dalteparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Anticoagulant impairment of hemostasis aggravates injection-site bleeding caused by collagenase-induced tissue disruption.
What to do
Where feasible, delay collagenase treatment or hold dalteparin as judged by the prescriber. Monitor the injection site for hematoma.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Collagenase clostridium histolyticum with Dalteparin?
MediHelp rates the interaction as moderate. Collagenase clostridium histolyticum and Dalteparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Collagenase injections frequently cause bruising and bleeding at the injection site, and anticoagulants may increase the risk of hematoma. Labeling advises against anticoagulants except low-dose aspirin.
How serious is the interaction between Collagenase clostridium histolyticum and Dalteparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where feasible, delay collagenase treatment or hold dalteparin as judged by the prescriber. Monitor the injection site for hematoma.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
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