Drug interactions
Collagenase clostridium histolyticum + Fondaparinux
Severity: Moderate
Collagenase clostridium histolyticum and Fondaparinux: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Collagenase injection for Dupuytren contracture or Peyronie disease commonly causes ecchymosis and bleeding at the injection site, and anticoagulants may worsen this. Labeling advises caution with anticoagulants.
What this interaction means in plain words
Collagenase clostridium histolyticum and Fondaparinux can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Anticoagulant effect adds to collagenase-induced local tissue disruption and bleeding.
What to do
Consider timing the injection relative to fondaparinux dosing where it is safe to do so. Monitor for injection-site hematoma and bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fondaparinux
- Defibrotide + Fondaparinux Contraindicated
- Fondaparinux + Ketorolac Contraindicated
- Abciximab + Fondaparinux Major
- Aceclofenac + Fondaparinux Major
- Acetylsalicylic acid + Fondaparinux Major
- Alteplase + Fondaparinux Major
Frequently asked questions
Can I take Collagenase clostridium histolyticum with Fondaparinux?
MediHelp rates the interaction as moderate. Collagenase clostridium histolyticum and Fondaparinux can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Collagenase injection for Dupuytren contracture or Peyronie disease commonly causes ecchymosis and bleeding at the injection site, and anticoagulants may worsen this. Labeling advises caution with anticoagulants.
How serious is the interaction between Collagenase clostridium histolyticum and Fondaparinux?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider timing the injection relative to fondaparinux dosing where it is safe to do so. Monitor for injection-site hematoma and bleeding.
What other medicines interact with Fondaparinux?
MediHelp also lists interactions of Fondaparinux with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Fondaparinux page.
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