Drug interactions
Collagenase clostridium histolyticum + Rivaroxaban
Severity: Moderate
Collagenase clostridium histolyticum and Rivaroxaban: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Collagenase injections frequently cause bruising and bleeding at the injection site, and anticoagulants can make this worse. Rare serious bleeding such as corporal rupture or hematoma is also a concern.
What this interaction means in plain words
Collagenase clostridium histolyticum and Rivaroxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic effect: anticoagulation adds to local tissue disruption and bleeding from collagenase injection.
What to do
Avoid giving collagenase to patients on anticoagulants unless the prescriber judges it necessary, with only low-dose aspirin tolerated. Watch the injection site for hematoma and bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rivaroxaban
- Defibrotide + Rivaroxaban Contraindicated
- Ketoconazole + Rivaroxaban Contraindicated
- Ketorolac + Rivaroxaban Contraindicated
- Abciximab + Rivaroxaban Major
- Acalabrutinib + Rivaroxaban Major
- Acetylsalicylic acid + Rivaroxaban Major
Frequently asked questions
Can I take Collagenase clostridium histolyticum with Rivaroxaban?
MediHelp rates the interaction as moderate. Collagenase clostridium histolyticum and Rivaroxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Collagenase injections frequently cause bruising and bleeding at the injection site, and anticoagulants can make this worse. Rare serious bleeding such as corporal rupture or hematoma is also a concern.
How serious is the interaction between Collagenase clostridium histolyticum and Rivaroxaban?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving collagenase to patients on anticoagulants unless the prescriber judges it necessary, with only low-dose aspirin tolerated. Watch the injection site for hematoma and bleeding.
What other medicines interact with Rivaroxaban?
MediHelp also lists interactions of Rivaroxaban with, for example, Defibrotide, Ketoconazole, Ketorolac. The full list is on the Rivaroxaban page.
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