Drug interactions
Defibrotide + Rivaroxaban
Severity: Contraindicated
Defibrotide and Rivaroxaban: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Defibrotide has antithrombotic and profibrinolytic activity, and adding rivaroxaban increases the chance of serious bleeding. Defibrotide labeling contraindicates concurrent systemic anticoagulants.
What this interaction means in plain words
Defibrotide and Rivaroxaban are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Defibrotide belongs to Cardiovascular; Rivaroxaban belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effects on hemostasis from factor Xa inhibition plus enhanced fibrinolysis.
What to do
Do not co-administer; interrupt rivaroxaban during defibrotide therapy per specialist advice. Central line maintenance is the usual exception.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Rivaroxaban
- Ketoconazole + Rivaroxaban Contraindicated
- Ketorolac + Rivaroxaban Contraindicated
- Abciximab + Rivaroxaban Major
- Acalabrutinib + Rivaroxaban Major
- Acetylsalicylic acid + Rivaroxaban Major
- Alteplase + Rivaroxaban Major
Other interactions of Defibrotide
- Alteplase + Defibrotide Contraindicated
- Apixaban + Defibrotide Contraindicated
- Argatroban + Defibrotide Contraindicated
- Dabigatran etexilate + Defibrotide Contraindicated
- Dalteparin + Defibrotide Contraindicated
- Defibrotide + Edoxaban Contraindicated
Frequently asked questions
Can I take Defibrotide with Rivaroxaban?
MediHelp rates the interaction as contraindicated. Defibrotide and Rivaroxaban are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Defibrotide has antithrombotic and profibrinolytic activity, and adding rivaroxaban increases the chance of serious bleeding. Defibrotide labeling contraindicates concurrent systemic anticoagulants.
How serious is the interaction between Defibrotide and Rivaroxaban?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; interrupt rivaroxaban during defibrotide therapy per specialist advice. Central line maintenance is the usual exception.
What other medicines interact with Rivaroxaban?
MediHelp also lists interactions of Rivaroxaban with, for example, Ketoconazole, Ketorolac, Abciximab. The full list is on the Rivaroxaban page.
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