Drug interactions
ketoconazole + rivaroxaban
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Marked ↑ rivaroxaban; contraindicated/avoid.
Mechanism of action
Strong CYP3A4/P-gp inhibition.
Clinical management
Avoid coadministration.
Drug reference
References
Frequently asked questions
Can I take ketoconazole with rivaroxaban?
The interaction is rated: Contraindicated. Marked ↑ rivaroxaban; contraindicated/avoid.
How serious is the interaction between ketoconazole and rivaroxaban?
The interaction is rated: Contraindicated. Evidence level: High.
How is the interaction between ketoconazole and rivaroxaban managed?
Avoid coadministration.
Why do ketoconazole and rivaroxaban interact?
Strong CYP3A4/P-gp inhibition.
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