Drug interactions
Conivaptan + Dapsone
Severity: Minor
Conivaptan and Dapsone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan inhibits CYP3A4 and may raise dapsone levels. Increased exposure could heighten the risk of hematologic toxicity, though conivaptan is given only short term.
What this interaction means in plain words
Conivaptan and Dapsone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Conivaptan inhibits CYP3A4, decreasing dapsone clearance.
What to do
Monitor for methemoglobinemia and hemolysis during the short conivaptan course. No empiric dose change is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Frequently asked questions
Can I take Conivaptan with Dapsone?
MediHelp rates the interaction as minor. Conivaptan and Dapsone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Conivaptan inhibits CYP3A4 and may raise dapsone levels. Increased exposure could heighten the risk of hematologic toxicity, though conivaptan is given only short term.
How serious is the interaction between Conivaptan and Dapsone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for methemoglobinemia and hemolysis during the short conivaptan course. No empiric dose change is usually needed.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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