Drug interactions
Conivaptan + Dasatinib
Severity: Major
Conivaptan and Dasatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a strong CYP3A4 inhibitor and can raise dasatinib concentrations. This increases the risk of myelosuppression, fluid retention and QT effects.
What this interaction means in plain words
Conivaptan and Dasatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Conivaptan inhibits CYP3A4, decreasing dasatinib clearance.
What to do
Avoid if possible, given conivaptan is used short term. If needed, consider reducing the dasatinib dose or holding it, and monitor blood counts, ECG and fluid status.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Conivaptan with Dasatinib?
MediHelp rates the interaction as major. Conivaptan and Dasatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Conivaptan is a strong CYP3A4 inhibitor and can raise dasatinib concentrations. This increases the risk of myelosuppression, fluid retention and QT effects.
How serious is the interaction between Conivaptan and Dasatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, given conivaptan is used short term. If needed, consider reducing the dasatinib dose or holding it, and monitor blood counts, ECG and fluid status.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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