Drug interactions
Conivaptan + Ethinyl estradiol-drospirenone
Severity: Moderate
Conivaptan and Ethinyl estradiol-drospirenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a CYP3A4 inhibitor and may raise exposure to ethinyl estradiol and drospirenone. Increased drospirenone exposure carries potassium-raising potential, and estrogen effects may increase. Conivaptan use is short-term and in hospitalized patients.
What this interaction means in plain words
Conivaptan and Ethinyl estradiol-drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Conivaptan inhibits CYP3A4, decreasing metabolism of both hormones.
What to do
Monitor serum potassium and blood pressure during conivaptan therapy. Consider temporarily holding the contraceptive if clinically appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Frequently asked questions
Can I take Conivaptan with Ethinyl estradiol-drospirenone?
MediHelp rates the interaction as moderate. Conivaptan and Ethinyl estradiol-drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Conivaptan is a CYP3A4 inhibitor and may raise exposure to ethinyl estradiol and drospirenone. Increased drospirenone exposure carries potassium-raising potential, and estrogen effects may increase. Conivaptan use is short-term and in hospitalized patients.
How serious is the interaction between Conivaptan and Ethinyl estradiol-drospirenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure during conivaptan therapy. Consider temporarily holding the contraceptive if clinically appropriate.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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