Drug interactions
Conivaptan + Fluvoxamine
Severity: Minor
Conivaptan and Fluvoxamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a CYP3A4 substrate, and fluvoxamine is a weak CYP3A4 inhibitor, so conivaptan exposure could rise somewhat. Excessive aquaresis or overly rapid sodium correction is the main concern.
What this interaction means in plain words
Conivaptan and Fluvoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Fluvoxamine weakly inhibits CYP3A4, reducing conivaptan metabolism.
What to do
Monitor serum sodium frequently during conivaptan therapy, as is standard, and watch for overly rapid correction.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Conivaptan with Fluvoxamine?
MediHelp rates the interaction as minor. Conivaptan and Fluvoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Conivaptan is a CYP3A4 substrate, and fluvoxamine is a weak CYP3A4 inhibitor, so conivaptan exposure could rise somewhat. Excessive aquaresis or overly rapid sodium correction is the main concern.
How serious is the interaction between Conivaptan and Fluvoxamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium frequently during conivaptan therapy, as is standard, and watch for overly rapid correction.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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