Drug interactions
Disopyramide + Itraconazole
Severity: Contraindicated
Disopyramide and Itraconazole: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole raises disopyramide concentrations and both drugs prolong the QT interval. This can cause torsades de pointes and other serious arrhythmias, as well as anticholinergic and hypoglycemic effects from high disopyramide levels.
What this interaction means in plain words
Disopyramide and Itraconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Disopyramide belongs to Cardiovascular; Itraconazole belongs to Anti Fungals.
Why it happens
CYP3A4 inhibition raises disopyramide levels, with additive QT prolongation.
What to do
Avoid the combination. Use a non-interacting antiarrhythmic or an antifungal without CYP3A4 inhibition.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Disopyramide with Itraconazole?
MediHelp rates the interaction as contraindicated. Disopyramide and Itraconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Itraconazole raises disopyramide concentrations and both drugs prolong the QT interval. This can cause torsades de pointes and other serious arrhythmias, as well as anticholinergic and hypoglycemic effects from high disopyramide levels.
How serious is the interaction between Disopyramide and Itraconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Use a non-interacting antiarrhythmic or an antifungal without CYP3A4 inhibition.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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