Drug interactions
Conivaptan + Omeprazole
Severity: Minor
Conivaptan and Omeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan inhibits CYP3A4, a secondary pathway of omeprazole metabolism. Omeprazole exposure could increase somewhat, but clinical consequences are unlikely given the short course of conivaptan and omeprazole's wide therapeutic margin.
What this interaction means in plain words
Conivaptan and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Conivaptan inhibits CYP3A4, slightly reducing omeprazole clearance.
What to do
No dose adjustment is usually needed. Watch for omeprazole adverse effects only if high doses are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Frequently asked questions
Can I take Conivaptan with Omeprazole?
MediHelp rates the interaction as minor. Conivaptan and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Conivaptan inhibits CYP3A4, a secondary pathway of omeprazole metabolism. Omeprazole exposure could increase somewhat, but clinical consequences are unlikely given the short course of conivaptan and omeprazole's wide therapeutic margin.
How serious is the interaction between Conivaptan and Omeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Watch for omeprazole adverse effects only if high doses are used.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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