Drug interactions
Conivaptan + Ruxolitinib
Severity: Major
Conivaptan and Ruxolitinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a CYP3A4 inhibitor and increases ruxolitinib exposure. This may worsen cytopenias and infection risk.
What this interaction means in plain words
Conivaptan and Ruxolitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
CYP3A4 inhibition by conivaptan reduces ruxolitinib metabolism.
What to do
Reduce the ruxolitinib dose per labeling when a strong CYP3A4 inhibitor is used. Monitor blood counts closely, noting conivaptan is used short-term in hospital.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ruxolitinib
Frequently asked questions
Can I take Conivaptan with Ruxolitinib?
MediHelp rates the interaction as major. Conivaptan and Ruxolitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Conivaptan is a CYP3A4 inhibitor and increases ruxolitinib exposure. This may worsen cytopenias and infection risk.
How serious is the interaction between Conivaptan and Ruxolitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the ruxolitinib dose per labeling when a strong CYP3A4 inhibitor is used. Monitor blood counts closely, noting conivaptan is used short-term in hospital.
What other medicines interact with Ruxolitinib?
MediHelp also lists interactions of Ruxolitinib with, for example, Atazanavir, Ceritinib, Chloramphenicol. The full list is on the Ruxolitinib page.
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