Drug interactions
Chloramphenicol + Ruxolitinib
Severity: Major
Chloramphenicol and Ruxolitinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ruxolitinib is metabolized mainly by CYP3A4, so inhibition raises exposure and may deepen cytopenias. Chloramphenicol also suppresses bone marrow.
What this interaction means in plain words
Chloramphenicol and Ruxolitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Ruxolitinib belongs to Oncology.
Why it happens
Chloramphenicol inhibits CYP3A4 and adds myelosuppression.
What to do
Reduce the ruxolitinib dose as labeled for CYP3A4 inhibitors in myelofibrosis or polycythemia vera. Monitor complete blood counts frequently.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chloramphenicol
Other interactions of Ruxolitinib
- Atazanavir + Ruxolitinib Major
- Ceritinib + Ruxolitinib Major
- Cobicistat + Ruxolitinib Major
- Conivaptan + Ruxolitinib Major
- Darunavir + Ruxolitinib Major
- Deferiprone + Ruxolitinib Major
Frequently asked questions
Can I take Chloramphenicol with Ruxolitinib?
MediHelp rates the interaction as major. Chloramphenicol and Ruxolitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ruxolitinib is metabolized mainly by CYP3A4, so inhibition raises exposure and may deepen cytopenias. Chloramphenicol also suppresses bone marrow.
How serious is the interaction between Chloramphenicol and Ruxolitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the ruxolitinib dose as labeled for CYP3A4 inhibitors in myelofibrosis or polycythemia vera. Monitor complete blood counts frequently.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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