Drug interactions
Ceritinib + Ruxolitinib
Severity: Major
Ceritinib and Ruxolitinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib is a strong CYP3A4 inhibitor and can raise ruxolitinib exposure, increasing thrombocytopenia, anemia, neutropenia and infection risk.
What this interaction means in plain words
Ceritinib and Ruxolitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ceritinib belongs to Oncology; Ruxolitinib belongs to Oncology.
Why it happens
CYP3A4 inhibition by ceritinib reduces ruxolitinib metabolism.
What to do
Reduce the ruxolitinib dose as recommended for strong CYP3A4 inhibitors. Monitor complete blood counts closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ruxolitinib
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Ruxolitinib?
MediHelp rates the interaction as major. Ceritinib and Ruxolitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ceritinib is a strong CYP3A4 inhibitor and can raise ruxolitinib exposure, increasing thrombocytopenia, anemia, neutropenia and infection risk.
How serious is the interaction between Ceritinib and Ruxolitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the ruxolitinib dose as recommended for strong CYP3A4 inhibitors. Monitor complete blood counts closely.
What other medicines interact with Ruxolitinib?
MediHelp also lists interactions of Ruxolitinib with, for example, Atazanavir, Chloramphenicol, Cobicistat. The full list is on the Ruxolitinib page.
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