Drug interactions
Atazanavir + Ruxolitinib
Severity: Major
Atazanavir and Ruxolitinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir is a strong CYP3A4 inhibitor that increases ruxolitinib exposure, raising the risk of cytopenias and infection. Ruxolitinib labeling recommends dose reduction with strong CYP3A4 inhibitors.
What this interaction means in plain words
Atazanavir and Ruxolitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Ruxolitinib belongs to Oncology.
Why it happens
CYP3A4 inhibition by atazanavir reduces ruxolitinib clearance.
What to do
Reduce the ruxolitinib dose per labeling for the indication and platelet count. Monitor blood counts frequently and adjust the dose accordingly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ruxolitinib
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Ruxolitinib?
MediHelp rates the interaction as major. Atazanavir and Ruxolitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir is a strong CYP3A4 inhibitor that increases ruxolitinib exposure, raising the risk of cytopenias and infection. Ruxolitinib labeling recommends dose reduction with strong CYP3A4 inhibitors.
How serious is the interaction between Atazanavir and Ruxolitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the ruxolitinib dose per labeling for the indication and platelet count. Monitor blood counts frequently and adjust the dose accordingly.
What other medicines interact with Ruxolitinib?
MediHelp also lists interactions of Ruxolitinib with, for example, Ceritinib, Chloramphenicol, Cobicistat. The full list is on the Ruxolitinib page.
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