Drug interactions
Conjugated estrogens + Gemifloxacin
Severity: Minor
Conjugated estrogens and Gemifloxacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics have been proposed to lower estrogen exposure by disturbing gut flora involved in enterohepatic recycling. For fluoroquinolones there is little evidence of a clinically important reduction.
What this interaction means in plain words
Conjugated estrogens and Gemifloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical decrease in enterohepatic recirculation of estrogens due to altered gut flora; not established for this antibiotic.
What to do
No dose change is needed. Advise the patient to report breakthrough bleeding or a return of menopausal symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Conjugated estrogens with Gemifloxacin?
MediHelp rates the interaction as minor. Conjugated estrogens and Gemifloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibiotics have been proposed to lower estrogen exposure by disturbing gut flora involved in enterohepatic recycling. For fluoroquinolones there is little evidence of a clinically important reduction.
How serious is the interaction between Conjugated estrogens and Gemifloxacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Advise the patient to report breakthrough bleeding or a return of menopausal symptoms.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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