Drug interactions
Conjugated estrogens + Tacrolimus
Severity: Minor
Conjugated estrogens and Tacrolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus may inhibit P-glycoprotein and theoretically increase exposure to estrogen components that are transported by it. The clinical relevance is likely small and would show up as estrogenic adverse effects.
What this interaction means in plain words
Conjugated estrogens and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Tacrolimus may inhibit P-gp efflux of estrogens; the effect is largely theoretical.
What to do
No routine adjustment is needed; watch for estrogen excess effects such as breast tenderness or fluid retention and adjust the estrogen dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Conjugated estrogens with Tacrolimus?
MediHelp rates the interaction as minor. Conjugated estrogens and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tacrolimus may inhibit P-glycoprotein and theoretically increase exposure to estrogen components that are transported by it. The clinical relevance is likely small and would show up as estrogenic adverse effects.
How serious is the interaction between Conjugated estrogens and Tacrolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; watch for estrogen excess effects such as breast tenderness or fluid retention and adjust the estrogen dose if they occur.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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