Drug interactions
Conjugated estrogens vaginal + Voriconazole
Severity: Minor
Conjugated estrogens vaginal and Voriconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vaginal conjugated estrogens produce low systemic exposure, so any increase from voriconazole is unlikely to be clinically important.
What this interaction means in plain words
Conjugated estrogens vaginal and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible CYP3A4 inhibition of estrogen metabolism, with limited systemic absorption.
What to do
No routine action is needed; be aware of estrogenic effects if symptoms such as breast tenderness arise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Conjugated estrogens vaginal with Voriconazole?
MediHelp rates the interaction as minor. Conjugated estrogens vaginal and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vaginal conjugated estrogens produce low systemic exposure, so any increase from voriconazole is unlikely to be clinically important.
How serious is the interaction between Conjugated estrogens vaginal and Voriconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; be aware of estrogenic effects if symptoms such as breast tenderness arise.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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