Drug interactions
Contrast media + Oxaliplatin
Severity: Minor
Contrast media and Oxaliplatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iodinated contrast can cause acute kidney injury, and oxaliplatin is cleared by the kidney. Impaired renal function may increase oxaliplatin exposure and toxicity. The clinical effect is usually modest in patients with normal renal function.
What this interaction means in plain words
Contrast media and Oxaliplatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Contrast-related nephrotoxicity may reduce renal elimination of oxaliplatin.
What to do
Ensure adequate hydration and check serum creatinine after contrast. Follow oxaliplatin labeling for dosing in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Contrast media with Oxaliplatin?
MediHelp rates the interaction as minor. Contrast media and Oxaliplatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Iodinated contrast can cause acute kidney injury, and oxaliplatin is cleared by the kidney. Impaired renal function may increase oxaliplatin exposure and toxicity. The clinical effect is usually modest in patients with normal renal function.
How serious is the interaction between Contrast media and Oxaliplatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and check serum creatinine after contrast. Follow oxaliplatin labeling for dosing in renal impairment.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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