Drug interactions
Contrast media + Tacrolimus
Severity: Moderate
Contrast media and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iodinated contrast can cause contrast-associated kidney injury, and tacrolimus constricts afferent arterioles and is nephrotoxic. Together they raise the risk of acute kidney injury, especially in patients with existing renal impairment or dehydration.
What this interaction means in plain words
Contrast media and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity from tacrolimus-induced renal vasoconstriction and contrast-induced tubular injury and hemodynamic effects.
What to do
Ensure adequate hydration and use the lowest necessary contrast volume. Check serum creatinine and tacrolimus trough levels in the days after the procedure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Contrast media with Tacrolimus?
MediHelp rates the interaction as moderate. Contrast media and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iodinated contrast can cause contrast-associated kidney injury, and tacrolimus constricts afferent arterioles and is nephrotoxic. Together they raise the risk of acute kidney injury, especially in patients with existing renal impairment or dehydration.
How serious is the interaction between Contrast media and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and use the lowest necessary contrast volume. Check serum creatinine and tacrolimus trough levels in the days after the procedure.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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