Drug interactions
Copanlisib + Itraconazole
Severity: Major
Copanlisib and Itraconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole raises copanlisib exposure because copanlisib is cleared mainly through CYP3A4. Higher levels may increase toxicities such as hyperglycemia, hypertension, infections and pneumonitis.
What this interaction means in plain words
Copanlisib and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Strong CYP3A4 inhibition by itraconazole reduces the metabolic clearance of copanlisib.
What to do
Prefer an antifungal that does not inhibit CYP3A4 strongly. If the combination is unavoidable, reduce the copanlisib dose per labeling and monitor blood glucose, blood pressure and signs of infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Copanlisib with Itraconazole?
MediHelp rates the interaction as major. Copanlisib and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole raises copanlisib exposure because copanlisib is cleared mainly through CYP3A4. Higher levels may increase toxicities such as hyperglycemia, hypertension, infections and pneumonitis.
How serious is the interaction between Copanlisib and Itraconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antifungal that does not inhibit CYP3A4 strongly. If the combination is unavoidable, reduce the copanlisib dose per labeling and monitor blood glucose, blood pressure and signs of infection.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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