Drug interactions
Copanlisib + Ribociclib
Severity: Moderate
Copanlisib and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Copanlisib is metabolized mainly by CYP3A4, so ribociclib may increase its exposure. This may increase hyperglycemia, hypertension, infections and other adverse effects.
What this interaction means in plain words
Copanlisib and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ribociclib inhibits CYP3A4, reducing copanlisib clearance.
What to do
Monitor blood glucose, blood pressure and for infections. Consider reducing the copanlisib dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Copanlisib with Ribociclib?
MediHelp rates the interaction as moderate. Copanlisib and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Copanlisib is metabolized mainly by CYP3A4, so ribociclib may increase its exposure. This may increase hyperglycemia, hypertension, infections and other adverse effects.
How serious is the interaction between Copanlisib and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, blood pressure and for infections. Consider reducing the copanlisib dose if toxicity develops.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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