Drug interactions
Cornsilk + Eplerenone
Severity: Minor
Cornsilk and Eplerenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cornsilk is reputed to have a mild diuretic effect and some preparations contain potassium. An additive effect with eplerenone on fluid, electrolytes and blood pressure is possible but is not well documented.
What this interaction means in plain words
Cornsilk and Eplerenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive diuretic or potassium-related effects; the mechanism is not well established.
What to do
Ask patients about herbal product use, and monitor serum potassium if cornsilk is taken regularly with eplerenone.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Frequently asked questions
Can I take Cornsilk with Eplerenone?
MediHelp rates the interaction as minor. Cornsilk and Eplerenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cornsilk is reputed to have a mild diuretic effect and some preparations contain potassium. An additive effect with eplerenone on fluid, electrolytes and blood pressure is possible but is not well documented.
How serious is the interaction between Cornsilk and Eplerenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask patients about herbal product use, and monitor serum potassium if cornsilk is taken regularly with eplerenone.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
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