Drug interactions
Corticotropin + Hydrochlorothiazide-olmesartan
Severity: Moderate
Corticotropin and Hydrochlorothiazide-olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticotropin stimulates cortisol and mineralocorticoid release, which increases renal potassium loss and sodium retention. With hydrochlorothiazide this can produce hypokalemia and oppose blood pressure control.
What this interaction means in plain words
Corticotropin and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Corticotropin belongs to Endocrine; Hydrochlorothiazide-olmesartan belongs to Cardiovascular.
Why it happens
Corticotropin-induced mineralocorticoid effect adds to thiazide kaliuresis.
What to do
Monitor serum potassium and blood pressure during corticotropin therapy and supplement potassium if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Corticotropin
Frequently asked questions
Can I take Corticotropin with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as moderate. Corticotropin and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticotropin stimulates cortisol and mineralocorticoid release, which increases renal potassium loss and sodium retention. With hydrochlorothiazide this can produce hypokalemia and oppose blood pressure control.
How serious is the interaction between Corticotropin and Hydrochlorothiazide-olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure during corticotropin therapy and supplement potassium if needed.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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