Drug interactions
Corticotropin + Somatropin
Severity: Moderate
Corticotropin and Somatropin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticotropin raises endogenous glucocorticoid levels, and excess glucocorticoid can blunt the growth-promoting effect of somatropin. Somatropin also alters cortisol activation, which may unmask adrenal insufficiency.
What this interaction means in plain words
Corticotropin and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Corticotropin belongs to Endocrine; Somatropin belongs to Endocrine.
Why it happens
Glucocorticoid excess antagonizes growth hormone action, and growth hormone inhibits 11-beta-HSD1 conversion of cortisone to cortisol.
What to do
Monitor growth velocity in children and adjust somatropin dose as needed. Reassess adrenal function and glucocorticoid replacement when somatropin is started or changed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Somatropin
- Acarbose + Somatropin Moderate
- Albiglutide + Somatropin Moderate
- Alogliptin-metformin + Somatropin Moderate
- Alogliptin-pioglitazone + Somatropin Moderate
- Alogliptin + Somatropin Moderate
- Betamethasone + Somatropin Moderate
Other interactions of Corticotropin
Frequently asked questions
Can I take Corticotropin with Somatropin?
MediHelp rates the interaction as moderate. Corticotropin and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticotropin raises endogenous glucocorticoid levels, and excess glucocorticoid can blunt the growth-promoting effect of somatropin. Somatropin also alters cortisol activation, which may unmask adrenal insufficiency.
How serious is the interaction between Corticotropin and Somatropin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor growth velocity in children and adjust somatropin dose as needed. Reassess adrenal function and glucocorticoid replacement when somatropin is started or changed.
What other medicines interact with Somatropin?
MediHelp also lists interactions of Somatropin with, for example, Acarbose, Albiglutide, Alogliptin-metformin. The full list is on the Somatropin page.
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