Drug interactions
Corticotropin + Tofacitinib
Severity: Moderate
Corticotropin and Tofacitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticotropin stimulates cortisol release and has immunosuppressive effects at therapeutic doses. Combined with tofacitinib it may increase susceptibility to infection.
What this interaction means in plain words
Corticotropin and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Corticotropin belongs to Endocrine; Tofacitinib belongs to Musculoskeletal.
Why it happens
Additive immunosuppression from corticosteroid effects and JAK inhibition.
What to do
Use the lowest effective corticotropin dose and duration, and monitor for infections. Consider whether both agents are needed concurrently.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Other interactions of Corticotropin
Frequently asked questions
Can I take Corticotropin with Tofacitinib?
MediHelp rates the interaction as moderate. Corticotropin and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticotropin stimulates cortisol release and has immunosuppressive effects at therapeutic doses. Combined with tofacitinib it may increase susceptibility to infection.
How serious is the interaction between Corticotropin and Tofacitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective corticotropin dose and duration, and monitor for infections. Consider whether both agents are needed concurrently.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
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