Drug interactions
Cortisone + Dalteparin
Severity: Moderate
Cortisone and Dalteparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids can damage gastric mucosa and vascular integrity, which may raise bleeding risk in patients on dalteparin. Some effects on coagulability have also been described.
What this interaction means in plain words
Cortisone and Dalteparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic: corticosteroid-related mucosal injury and vascular fragility add to dalteparin anticoagulation.
What to do
Monitor for bleeding, especially gastrointestinal, and use the lowest effective steroid dose for the shortest time. Consider gastroprotection in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Cortisone with Dalteparin?
MediHelp rates the interaction as moderate. Cortisone and Dalteparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroids can damage gastric mucosa and vascular integrity, which may raise bleeding risk in patients on dalteparin. Some effects on coagulability have also been described.
How serious is the interaction between Cortisone and Dalteparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding, especially gastrointestinal, and use the lowest effective steroid dose for the shortest time. Consider gastroprotection in high-risk patients.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
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