Drug interactions
Cortisone + Eplerenone
Severity: Minor
Cortisone and Eplerenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids can induce CYP3A4 only weakly, so the effect on eplerenone levels is likely small. Cortisone also has mineralocorticoid activity that causes sodium retention and potassium loss, which opposes eplerenone.
What this interaction means in plain words
Cortisone and Eplerenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 induction, plus mineralocorticoid effects that pharmacodynamically oppose aldosterone blockade.
What to do
Monitor blood pressure, fluid status and serum potassium during systemic cortisone therapy. Adjust the eplerenone dose if response changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Frequently asked questions
Can I take Cortisone with Eplerenone?
MediHelp rates the interaction as minor. Cortisone and Eplerenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Corticosteroids can induce CYP3A4 only weakly, so the effect on eplerenone levels is likely small. Cortisone also has mineralocorticoid activity that causes sodium retention and potassium loss, which opposes eplerenone.
How serious is the interaction between Cortisone and Eplerenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and serum potassium during systemic cortisone therapy. Adjust the eplerenone dose if response changes.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
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