Drug interactions
Cortisone + Fluvoxamine
Severity: Minor
Cortisone and Fluvoxamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cortisone is converted to active cortisol and is also cleared in part via CYP3A4. Fluvoxamine is only a weak CYP3A4 inhibitor, so any increase in corticosteroid exposure is likely small.
What this interaction means in plain words
Cortisone and Fluvoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 inhibition by fluvoxamine may slightly slow corticosteroid clearance.
What to do
No adjustment is usually needed; monitor for corticosteroid excess with prolonged use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Cortisone with Fluvoxamine?
MediHelp rates the interaction as minor. Cortisone and Fluvoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cortisone is converted to active cortisol and is also cleared in part via CYP3A4. Fluvoxamine is only a weak CYP3A4 inhibitor, so any increase in corticosteroid exposure is likely small.
How serious is the interaction between Cortisone and Fluvoxamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is usually needed; monitor for corticosteroid excess with prolonged use.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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