Drug interactions
Cortisone + Gemifloxacin
Severity: Moderate
Cortisone and Gemifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids such as cortisone increase the risk of tendinitis and tendon rupture associated with fluoroquinolones. The risk is higher in older patients and with prolonged steroid courses.
What this interaction means in plain words
Cortisone and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive tendon toxicity from impaired collagen synthesis by corticosteroids and fluoroquinolone-induced tenocyte damage.
What to do
Prefer a non-quinolone antibiotic in older patients or those on long-term steroids. Counsel patients to stop gemifloxacin and rest the limb if tendon pain or swelling occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Cortisone with Gemifloxacin?
MediHelp rates the interaction as moderate. Cortisone and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroids such as cortisone increase the risk of tendinitis and tendon rupture associated with fluoroquinolones. The risk is higher in older patients and with prolonged steroid courses.
How serious is the interaction between Cortisone and Gemifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-quinolone antibiotic in older patients or those on long-term steroids. Counsel patients to stop gemifloxacin and rest the limb if tendon pain or swelling occurs.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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