Drug interactions
Cortisone + Hydrochlorothiazide-lisinopril
Severity: Moderate
Cortisone and Hydrochlorothiazide-lisinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cortisone and hydrochlorothiazide both promote urinary potassium loss, so together they can cause hypokalemia. Corticosteroid sodium retention may also oppose the antihypertensive effect.
What this interaction means in plain words
Cortisone and Hydrochlorothiazide-lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive renal potassium wasting from thiazide action and corticosteroid mineralocorticoid effect.
What to do
Monitor serum potassium and blood pressure, particularly with prolonged corticosteroid courses. Replace potassium if needed; lisinopril may partly offset losses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Frequently asked questions
Can I take Cortisone with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as moderate. Cortisone and Hydrochlorothiazide-lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cortisone and hydrochlorothiazide both promote urinary potassium loss, so together they can cause hypokalemia. Corticosteroid sodium retention may also oppose the antihypertensive effect.
How serious is the interaction between Cortisone and Hydrochlorothiazide-lisinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure, particularly with prolonged corticosteroid courses. Replace potassium if needed; lisinopril may partly offset losses.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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