Drug interactions
Cortisone + Liraglutide
Severity: Moderate
Cortisone and Liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids such as cortisone raise blood glucose and can offset the glucose-lowering effect of liraglutide. Glycemic control may deteriorate, particularly with higher doses or prolonged courses.
What this interaction means in plain words
Cortisone and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Corticosteroids increase hepatic gluconeogenesis and peripheral insulin resistance, pharmacodynamically opposing GLP-1 receptor agonist action.
What to do
Monitor blood glucose more frequently when starting, increasing or stopping cortisone. Adjust the antidiabetic regimen as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Liraglutide
Frequently asked questions
Can I take Cortisone with Liraglutide?
MediHelp rates the interaction as moderate. Cortisone and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroids such as cortisone raise blood glucose and can offset the glucose-lowering effect of liraglutide. Glycemic control may deteriorate, particularly with higher doses or prolonged courses.
How serious is the interaction between Cortisone and Liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting, increasing or stopping cortisone. Adjust the antidiabetic regimen as needed.
What other medicines interact with Liraglutide?
MediHelp also lists interactions of Liraglutide with, for example, Insulin degludec-liraglutide, Insulin glargine-lixisenatide, Alogliptin-metformin. The full list is on the Liraglutide page.
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