Drug interactions
Cortisone + Midazolam
Severity: Minor
Cortisone and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids may modestly induce CYP3A4, which could lower midazolam exposure and weaken its sedative or anxiolytic effect. The effect is generally small and variable, and is more relevant with prolonged high-dose steroid use.
What this interaction means in plain words
Cortisone and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak induction of CYP3A4-mediated midazolam metabolism by corticosteroids.
What to do
Titrate midazolam to clinical effect and be prepared to use a slightly higher dose in patients on sustained high-dose corticosteroids. No routine dose change is needed with short courses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Cortisone with Midazolam?
MediHelp rates the interaction as minor. Cortisone and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Corticosteroids may modestly induce CYP3A4, which could lower midazolam exposure and weaken its sedative or anxiolytic effect. The effect is generally small and variable, and is more relevant with prolonged high-dose steroid use.
How serious is the interaction between Cortisone and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate midazolam to clinical effect and be prepared to use a slightly higher dose in patients on sustained high-dose corticosteroids. No routine dose change is needed with short courses.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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