Drug interactions
Cortisone + Moxifloxacin
Severity: Moderate
Cortisone and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids such as cortisone increase the risk of tendinitis and tendon rupture associated with fluoroquinolones. The risk is higher in patients over 60, transplant recipients, and with long-term steroids.
What this interaction means in plain words
Cortisone and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive tendon toxicity: fluoroquinolones damage tenocytes while corticosteroids impair collagen synthesis and repair.
What to do
Use a non-quinolone antibiotic where feasible in older patients or those on long-term steroids. Counsel patients to stop moxifloxacin and rest at the first sign of tendon pain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Cortisone with Moxifloxacin?
MediHelp rates the interaction as moderate. Cortisone and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroids such as cortisone increase the risk of tendinitis and tendon rupture associated with fluoroquinolones. The risk is higher in patients over 60, transplant recipients, and with long-term steroids.
How serious is the interaction between Cortisone and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-quinolone antibiotic where feasible in older patients or those on long-term steroids. Counsel patients to stop moxifloxacin and rest at the first sign of tendon pain.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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