Drug interactions
Cortisone + Nabumetone
Severity: Moderate
Cortisone and Nabumetone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids taken with NSAIDs raise the risk of gastric and duodenal ulceration and gastrointestinal bleeding beyond that seen with either drug alone. Nabumetone is somewhat less gastrotoxic than other NSAIDs, but the risk is not eliminated.
What this interaction means in plain words
Cortisone and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive gastrointestinal mucosal injury: NSAID inhibition of protective prostaglandins plus corticosteroid impairment of mucosal healing.
What to do
Use the lowest effective doses for the shortest time and consider adding a proton pump inhibitor in at-risk patients. Counsel patients to report black stools, hematemesis or severe epigastric pain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Frequently asked questions
Can I take Cortisone with Nabumetone?
MediHelp rates the interaction as moderate. Cortisone and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids taken with NSAIDs raise the risk of gastric and duodenal ulceration and gastrointestinal bleeding beyond that seen with either drug alone. Nabumetone is somewhat less gastrotoxic than other NSAIDs, but the risk is not eliminated.
How serious is the interaction between Cortisone and Nabumetone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest time and consider adding a proton pump inhibitor in at-risk patients. Counsel patients to report black stools, hematemesis or severe epigastric pain.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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