Drug interactions
Cortisone + Piroxicam
Severity: Moderate
Cortisone and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent corticosteroids and NSAIDs increase the risk of peptic ulceration and gastrointestinal bleeding beyond either drug alone. The risk is greater in older patients and with prolonged use.
What this interaction means in plain words
Cortisone and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAIDs impair gastric mucosal prostaglandin protection while corticosteroids impair mucosal healing, producing additive ulcer risk.
What to do
Use the lowest effective doses for the shortest duration and consider a proton pump inhibitor for gastroprotection. Monitor for dyspepsia, melena or anemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Cortisone with Piroxicam?
MediHelp rates the interaction as moderate. Cortisone and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent corticosteroids and NSAIDs increase the risk of peptic ulceration and gastrointestinal bleeding beyond either drug alone. The risk is greater in older patients and with prolonged use.
How serious is the interaction between Cortisone and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest duration and consider a proton pump inhibitor for gastroprotection. Monitor for dyspepsia, melena or anemia.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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