Drug interactions
Cortisone + Rosiglitazone
Severity: Moderate
Cortisone and Rosiglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids such as cortisone cause insulin resistance and raise blood glucose. They can reduce the effectiveness of rosiglitazone and worsen glycemic control, particularly with sustained or high-dose use.
What this interaction means in plain words
Cortisone and Rosiglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism: glucocorticoids increase hepatic gluconeogenesis and peripheral insulin resistance.
What to do
Monitor blood glucose when cortisone is started, changed or withdrawn. Increase the antidiabetic dose as needed, and reduce it again when the corticosteroid is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Frequently asked questions
Can I take Cortisone with Rosiglitazone?
MediHelp rates the interaction as moderate. Cortisone and Rosiglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroids such as cortisone cause insulin resistance and raise blood glucose. They can reduce the effectiveness of rosiglitazone and worsen glycemic control, particularly with sustained or high-dose use.
How serious is the interaction between Cortisone and Rosiglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when cortisone is started, changed or withdrawn. Increase the antidiabetic dose as needed, and reduce it again when the corticosteroid is stopped.
What other medicines interact with Rosiglitazone?
MediHelp also lists interactions of Rosiglitazone with, for example, Insulin aspart protamine / insulin aspart, Insulin aspart-insulin aspart protamine, Insulin aspart. The full list is on the Rosiglitazone page.
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