Drug interactions
Cortisone + Saxagliptin
Severity: Moderate
Cortisone and Saxagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids raise blood glucose and can counteract saxagliptin, with larger effects at higher doses or longer courses. Induction of CYP3A4 by cortisone is weak and of minor importance.
What this interaction means in plain words
Cortisone and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism through glucocorticoid-induced insulin resistance and hepatic glucose output, plus weak CYP3A4 induction.
What to do
Monitor blood glucose during corticosteroid therapy and after dose changes. Intensify antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Frequently asked questions
Can I take Cortisone with Saxagliptin?
MediHelp rates the interaction as moderate. Cortisone and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids raise blood glucose and can counteract saxagliptin, with larger effects at higher doses or longer courses. Induction of CYP3A4 by cortisone is weak and of minor importance.
How serious is the interaction between Cortisone and Saxagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during corticosteroid therapy and after dose changes. Intensify antidiabetic therapy as needed.
What other medicines interact with Saxagliptin?
MediHelp also lists interactions of Saxagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Saxagliptin page.
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