Drug interactions
Cortisone + Sirolimus
Severity: Minor
Cortisone and Sirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids can induce CYP3A4 modestly, which might lower sirolimus levels. In practice they are routinely co-prescribed in transplant regimens, and any pharmacokinetic effect is generally small.
What this interaction means in plain words
Cortisone and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak induction of CYP3A4 by cortisone increasing sirolimus metabolism.
What to do
No routine change is needed. Follow sirolimus trough levels when corticosteroid doses change substantially.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Cortisone with Sirolimus?
MediHelp rates the interaction as minor. Cortisone and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Corticosteroids can induce CYP3A4 modestly, which might lower sirolimus levels. In practice they are routinely co-prescribed in transplant regimens, and any pharmacokinetic effect is generally small.
How serious is the interaction between Cortisone and Sirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Follow sirolimus trough levels when corticosteroid doses change substantially.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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